Physical Organic Chemistry

Course Description

Content:
Stereochemistry, (Chirality, R and S, optical activity), Fischer and Newman projection, meso compounds, reactions of alkyl halides, substitution and elimination, first and second order nucleophilic substitution, elimination reaction, elimination mechanisms, aromatic substitution, free- radical reactions, polar addition and elimination reactions, Carboanions and other nucleophilic carbon species, reactions of carbonyl compounds, free- radical substitution reaction, Rearrangement and fragmentation reactions.

Course Objectives & Outcomes

Objectives:

• Explaining and analyzing the stereochemistry of divers compounds.
• Solving problems demonstrating and understanding of fundamental reaction mechanisms.
• Relating the mechanisms of the reactions to stereochemistry of the organic compounds
•  Explaining various classes of organic reactions according to the appropriate mechanism, free radicals, and their reaction mechanisms.
• Trapping of intermediates.

Outcomes:
At the end of this course, the student will be able to:

• Determine the stereochemistry of divers compounds.
•  Solve problems demonstrating an understanding of fundamental mechanisms of elimination, addition and nucleophilic reactions.
• Relate the mechanisms of the reactions to stereochemistry of the organic compounds
•  Explain various classes of organic reaction according to the appropriate mechanisms.

References
Use both books:
1.Organic chemistry, L.G. Wade, JR. (8th edition), 2013, ISBN 978-0-321-76841-4 (0-321-76841-8) 1
Advanced organic chemistry, Part A: structure and mechanisms, F. A. Carey and R. J. Sundberg (5th edition), 2007, ISBN-13: 978-0-387-44897-8 (hard cover) e-ISBN-13: 978-0-387-44899-3, ISBN-13: 978-0-387-68346-1 (soft cover)

Course ID: CHEM 468